Food intake regulating-neuropeptides are expressed and regulated through pregnancy and following food restriction in rat placenta

Food intake regulating-neuropeptides are expressed and regulated through pregnancy and following food restriction in rat placenta

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Abstract Background Neuropeptide Y (NPY), agouti related peptide (AgRP), copyright and amphetamine-regulated transcript (CART) and melanocortins, the products of the proopiomelanocortin (POMC), are hypothalamic peptides involved in feeding regulation and energy homeostasis.Recent evidence has Hot Wheels demonstrated their expression in rat and human placenta.Methods In the current study, we have investigated the expression of those neuropeptides in the rat placenta by real-time PCR using a model of maternal food restriction.Results Our results showed that placental-derived neuropeptides were regulated through pregnancy and following food restriction.

Conclusion These data Massagers could indicate that placental-derived neuropeptides represent a local regulatory circuit that may fine-tune control of energy balance during pregnancy.